Author Correction Issued for Landmark Pig-to-Human Kidney Xenotransplant Study

The prestigious journal Nature has issued an author correction for a pivotal study titled "Physiology and immunology of a pig-to-human decedent kidney xenotransplant," originally published online on November 13, 2025. This correction addresses specific inaccuracies identified within the extended data figures of the groundbreaking research, which explored the feasibility and immunological response of transplanting a genetically modified pig kidney into a human recipient. Such amendments are a testament to the rigorous peer-review process and the scientific community's unwavering commitment to precision and transparency. The core of the correction pertains to two specific sections within the Extended Data Fig. 8. In Extended Data Fig. 8e, graph iv, the reported frequencies for various cell populations were initially provided as DN: 7.05%, DP: 67.2%, SPCD4: 10.8%, and SPCD8: 14.9%. These values have now been corrected to reflect the accurate measurements: DN: 18.8%, DP: 2.56%, SPCD: 0.32%, and SPCD8: 78.4%. Furthermore, in Extended Data Fig. 8f, graph iii, the percentage for hCD45 was erroneously listed as 48% and has been rectified to the correct value of 0.48%. These critical adjustments have been promptly implemented in both the HTML and PDF versions of the original article, ensuring that all readers and researchers accessing the study are presented with the most accurate and up-to-date information. The swift action to correct these figures highlights the meticulous standards upheld in scientific publishing, where even minor discrepancies are addressed to maintain the integrity of published data and the reliability of future research built upon these findings. The original study, despite these data corrections, remains a landmark achievement in the field of xenotransplantation. It represents a significant stride towards overcoming the critical shortage of human organs available for transplant, offering a potential future where genetically engineered animal organs could provide life-saving solutions. The research provided crucial insights into the physiological and immunological compatibility of a pig kidney within a human system, paving the way for further advancements in this complex and ethically sensitive area of medicine. The extensive collaborative effort behind this research involved numerous distinguished scientists and institutions. Key contributors, including Robert A. Montgomery, Jeffrey M. Stern, Farshid Fathi, and Nathan Suek, who contributed equally to the work, hailed from leading institutions such as the New York University Langone Transplant Institute, Columbia Center for Translational Immunology, and the New York University Grossman School of Medicine, among others. Their collective expertise underscores the multidisciplinary nature required for such pioneering medical breakthroughs.